Counterpoint: Early Salvage vs Adjuvant Radiotherapy for High-Risk Prostate Cancer.

Point: Early Salvage vs Adjuvant Radiotherapy for High-Risk Prostate Cancer. - PubMed - NCBI

Point: Early Salvage vs Adjuvant Radiotherapy for High-Risk Prostate Cancer.

By definition, adjuvant oncologic therapy refers to the postsurgical treatment of patients who are at high risk for recurrence but lack measurable disease. Adjuvant radiotherapy is considered a standard of care in a number of cancer types, including tumors of the breast, brain, head and neck, stomach, rectum, cervix, and endometrium, among others. In these cases, adjuvant radiation has been dem...

Reply from Authors re: Ronald C. Chen. Making Individualized Decisions in the Midst of Uncertainties: The Case of Prostate Cancer and Biochemical Recurrence. Eur Urol 2013;64:916–8: Optimal Timing for Postoperative Radiation: Still an Unanswered Question

[2] Trock BJ, Han M, Freedland SJ, et al. Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy. JAMA2008;299: 2760–9. [3] Stephenson AJ, Shariat SF, Zelefsky MJ, et al. Salvage radiotherapy for recurrent prostate cancer after radical prostatectomy. JAMA 2004; 291:1325–32. [4] Thompson IM, Tangen CM, Parade...

Who, when, where, and how: salvage prostate cancer with radiotherapy.

Despite the common use of postoperative radiotherapy (RT) in patients managed initially with radical prostatectomy (RP), a number of questions remain. Raldow and colleagues build their arguments around three randomized trials that indicated a significant benefit of immediate adjuvant radiotherapy in patients with high-risk features. They acknowledge that routine adjuvant radiotherapy might resu...

Very Early Salvage Radiotherapy Improves Distant Metastasis-Free Survival.

PURPOSE Early salvage radiotherapy following radical prostatectomy for prostate cancer is commonly advocated in place of adjuvant radiotherapy. We aimed to determine the optimal definition of early salvage radiotherapy. MATERIALS AND METHODS We performed a multi-institutional retrospective study of 657 men who underwent salvage radiotherapy between 1986 and 2013. Two comparisons were made to ...